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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071 Species: Homo sapiens RGD Object: Gene Symbol: AHR Name: aryl hydrocarbon receptor

Acc ID: CHEBI:7772 Term: omeprazole Definition: A sulfoxide having 3-methoxybenzimidazol-3-yl and 4-methoxy-3,5-dimethylpyridin-2-ylmethyl groups attached to the sulfur. CasRN: 73590-58-6 Chemical ID: MESH:D009853

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2074	6480464	CTD	Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]	PMID:9395520
multiple interactions	EXP		6480464	CTD	Omeprazole binds to and results in increased activity of AHR protein	PMID:9139728
increases activity	EXP		6480464	CTD	Omeprazole results in increased activity of AHR protein	PMID:16109480
multiple interactions	EXP		6480464	CTD	omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]	PMID:16109480
multiple interactions	ISO	RGD:2074	6480464	CTD	AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]	PMID:14742684
multiple interactions	EXP		6480464	CTD	AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA] AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]	PMID:20171196
multiple interactions	ISO	RGD:2074	6480464	CTD	[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA	PMID:22687989
multiple interactions	EXP		6480464	CTD	AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein] BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]	PMID:21861773
multiple interactions	EXP		6480464	CTD	AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA] Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter] Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]	PMID:21703235
increases activity	EXP		6480464	CTD	Omeprazole results in increased activity of AHR protein	PMID:16109480 PMID:21861773