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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731046 Species: Homo sapiens RGD Object: Gene Symbol: CCL2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:27504 Term: mitomycin C Definition: A mitomycin that has formula C15H18N4O5. CasRN: 50-07-7 Chemical ID: MESH:D016685

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Dexamethasone inhibits the reaction [Mitomycin results in increased secretion of CCL2 protein] Dexamethasone inhibits the reaction [Mitomycin results in increased expression of CCL2 mRNA]	PMID:20002897
increases expression	EXP		6480464	CTD	Mitomycin results in increased expression of CCL2 mRNA	PMID:20002897
increases secretion	EXP		6480464	CTD	Mitomycin results in increased secretion of CCL2 protein	PMID:20002897