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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731018 Species: Homo sapiens RGD Object: Gene Symbol: KDR Name: kinase insert domain receptor (a type III receptor tyrosine kinase)

Acc ID: CHEBI:4027 Term: cyclophosphamide Definition: A cyclic phosphorodiamide-based nitrogen mustard. CasRN: 50-18-0 Chemical ID: MESH:D003520

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:2965	6480464	CTD	Cyclophosphamide results in decreased expression of KDR mRNA Cyclophosphamide results in decreased expression of KDR protein	PMID:19701751
increases expression	ISO	RGD:2965	6480464	CTD	Cyclophosphamide results in increased expression of KDR mRNA	PMID:18632792