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GENE - TERM ANNOTATION REPORT

RGD ID: 730848 Species: Homo sapiens RGD Object: Gene Symbol: EDN1 Name: endothelin 1

Acc ID: RDO:0004932 Term: Asthma Definition: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
	IAGP		4144869	RGD	DNA:transition:intron:g.4124T>C (human)
	IEP		4144895	RGD	Severe Persistent Allergic Asthma protein:increased secretion:lung (human)