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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730848 Species: Homo sapiens RGD Object: Gene Symbol: EDN1 Name: endothelin 1

Acc ID: CHEBI:17234 Term: glucose Definition: null CasRN: 50-99-7 Chemical ID: MESH:D005947

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Glucose results in increased expression of EDN1 mRNA	PMID:20960276
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]	PMID:20960276
multiple interactions	ISO	RGD:2532	6480464	CTD	Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]	PMID:12821678
multiple interactions	EXP		6480464	CTD	carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]	PMID:16428915
increases expression	EXP		6480464	CTD	Glucose results in increased expression of EDN1 mRNA	PMID:16428915 PMID:20960276
increases expression	EXP		6480464	CTD	Glucose results in increased expression of EDN1 protein	PMID:16428915