GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
CasRN: 62-75-9
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:6213166480464CTDDimethylnitrosamine results in decreased activity of MMP2 protein

PMID:17348192
increases activityISORGD:6213166480464CTDDimethylnitrosamine results in increased activity of MMP2 protein

PMID:15161499
multiple interactionsISORGD:6213166480464CTDDrugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in decreased expression of MMP2 protein]

PMID:16965748
decreases expressionISORGD:6213166480464CTDDimethylnitrosamine results in decreased expression of MMP2 protein

PMID:16965748
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:16169303
PMID:16042886
PMID:15571005
PMID:17036385
multiple interactionsISORGD:6213166480464CTDDrugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]

PMID:17036385
multiple interactionsISORGD:6213166480464CTDpirfenidone inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]

PMID:15571005
multiple interactionsISORGD:6213166480464CTDPlant Preparations inhibits the reaction [Dimethylnitrosamine results in decreased activity of MMP2 protein]

PMID:17348192
multiple interactionsISORGD:6213166480464CTD[silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA]

PMID:16169303
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:16169303
PMID:15571005
PMID:17036385
PMID:16042886
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:15571005
PMID:17036385
PMID:16042886
PMID:16169303
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:17036385
PMID:15571005
PMID:16042886
PMID:16169303
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:15571005
PMID:17036385
PMID:16169303
PMID:16042886
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:15571005
PMID:16042886
PMID:17036385
PMID:16169303
increases expressionISORGD:6213166480464CTDDimethylnitrosamine results in increased expression of MMP2 mRNA

PMID:15571005
PMID:16042886
PMID:16169303
PMID:17036385
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