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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of ACE2 proteinPMID:29682576
Ace2multiple interactionsEXP 6480464CTD[INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]; ACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]; ACE2 inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; ACE2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]PMID:20844835 PMID:29682576
Ace2decreases expressionISOAce2 (Mus musculus)6480464CTDStreptozocin results in decreased expression of ACE2 proteinPMID:21381899 PMID:29266779
Ace2increases activityISOAce2 (Mus musculus)6480464CTDStreptozocin results in increased activity of ACE2 proteinPMID:28468961
Ace2multiple interactionsISOAce2 (Mus musculus)6480464CTD2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA]; [Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA; CEBPB protein inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA]; Telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]PMID:21381899 PMID:29266779 PMID:37120126
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