GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ace2 | increases activity | EXP | | 6480464 | CTD | Losartan results in increased activity of ACE2 protein | PMID:15897343 PMID:16221218 PMID:22009550 | Ace2 | increases expression | EXP | | 6480464 | CTD | Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein | PMID:15897343 PMID:28091615 | Ace2 | multiple interactions | EXP | | 6480464 | CTD | Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein] | PMID:16176966 PMID:20178811 | Ace2 | increases expression | ISO | Ace2 (Mus musculus) | 6480464 | CTD | Losartan results in increased expression of ACE2 protein | PMID:25655897 | Ace2 | multiple interactions | ISO | Ace2 (Mus musculus) | 6480464 | CTD | Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein] | PMID:25511041 PMID:33007385 | | ||||||||||||||||||||||
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