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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1c
Name: cyclin-dependent kinase inhibitor 1C
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1cdecreases methylationISOCdkn1c (Mus musculus)6480464CTDCadmium Chloride results in decreased methylation of CDKN1C promoterPMID:28823913
Cdkn1cincreases expressionISOCdkn1c (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CDKN1C mRNA; Cadmium Chloride results in increased expression of CDKN1C proteinPMID:28823913
Cdkn1cmultiple interactionsISOCdkn1c (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN1C mRNAPMID:35770551 PMID:36200916
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