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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp6
Name: caspase 6
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp6multiple interactionsISOCASP6 (Homo sapiens)6480464CTDbenzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 proteinPMID:21362627
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