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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp6
Name: caspase 6
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp6affects expressionISOCASP6 (Homo sapiens)6480464CTDFluorouracil affects the expression of CASP6 mRNAPMID:34151400
Casp6multiple interactionsISOCASP6 (Homo sapiens)6480464CTDFluorouracil results in increased cleavage of and results in increased activity of CASP6 protein; resveratrol affects the reaction [Fluorouracil results in increased activity of CASP6 protein]; TP53 affects the reaction [resveratrol affects the reaction [Fluorouracil results in increased activity of CASP6 protein]]PMID:18497562
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