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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70938
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il5ra
Name: interleukin 5 receptor subunit alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5raincreases expressionISOIl5ra (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IL5RA mRNA; Tetrachlorodibenzodioxin results in increased expression of IL5RA proteinPMID:11804338 PMID:20819909
Il5ramultiple interactionsISOIl5ra (Mus musculus)6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL5RA gene]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL5RA promoter]PMID:19654925 PMID:20819909
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