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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70913
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc5decreases expressionISOABCC5 (Homo sapiens)6480464CTDMethotrexate results in decreased expression of ABCC5 mRNAPMID:23897011
Abcc5decreases response to substanceISOABCC5 (Homo sapiens)6480464CTDABCC5 protein results in decreased susceptibility to MethotrexatePMID:15897250
Abcc5decreases response to substanceISOAbcc5 (Mus musculus)6480464CTDABCC5 mRNA results in decreased susceptibility to Methotrexate; ABCC5 protein results in decreased susceptibility to MethotrexatePMID:16918715
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