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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3increases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of EIF2AK3 proteinPMID:29111283
Eif2ak3increases expressionISOEIF2AK3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of EIF2AK3 mRNA; Arsenic Trioxide results in increased expression of EIF2AK3 protein modified formPMID:17963750 PMID:22922937
Eif2ak3increases expressionISOEif2ak3 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of EIF2AK3 protein modified formPMID:27638049
Eif2ak3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of EIF2AK3 proteinPMID:29111283
Eif2ak3multiple interactionsISOEIF2AK3 (Homo sapiens)6480464CTDsulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form]PMID:22922937
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTD2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form]PMID:27638049
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