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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3multiple interactionsEXP 6480464CTD[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified formPMID:20097184
Eif2ak3increases expressionISOEif2ak3 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of EIF2AK3 mRNAPMID:31919559
Eif2ak3increases phosphorylationISOEif2ak3 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased phosphorylation of EIF2AK3 proteinPMID:25827057
Eif2ak3multiple interactionsISOEif2ak3 (Mus musculus)6480464CTD1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein]PMID:25827057
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