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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3decreases response to substanceISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Akr1c3increases expressionISOAKR1C3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of AKR1C3 mRNAPMID:19128835 PMID:21461292 PMID:26705709
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C3 protein]PMID:26598702
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