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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Havcr1increases expressionISOHAVCR1 (Homo sapiens)6480464CTDParaquat results in increased expression of HAVCR1 mRNAPMID:34097952
Havcr1multiple interactionsISOHavcr1 (Mus musculus)6480464CTD[ABCB1A gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of HAVCR1 mRNA; [ABCB1B gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of HAVCR1 mRNA; [SLC47A1 gene mutant form results in increased susceptibility to Paraquat] which results in increased expression of HAVCR1 mRNAPMID:21991918 PMID:25015657
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