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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:61057
Term: tacrolimus hydrate
Definition: A hydrate that is the monohydrate form of tacrolimus.
Chemical ID: MESH:D016559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9affects metabolic processingISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 gene polymorphism affects the metabolism of Tacrolimus; CYP3A5 gene SNP affects the metabolism of Tacrolimus; CYP3A5 protein affects the metabolism of Tacrolimus; CYP3A5 protein polymorphism affects the metabolism of TacrolimusPMID:15502717 PMID:15729180 PMID:15808586 PMID:15919447 PMID:15964336
Cyp3a9affects response to substanceISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 gene affects the susceptibility to Tacrolimus; CYP3A5 polymorphism affects the susceptibility to TacrolimusPMID:15723604 PMID:36931438
Cyp3a9decreases methylationISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein results in decreased methylation of TacrolimusPMID:15951320
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]; CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]PMID:17377957 PMID:19384264
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