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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70836 Species: Homo sapiens RGD Object: Gene Symbol: LPL Name: lipoprotein lipase

Acc ID: CHEBI:44032 Term: indinavir Definition: A N-(2-hydroxyethyl)piperazine that has formula C36H47N5O4. CasRN: 150378-17-9 Chemical ID: MESH:D019469

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:10876	6480464	CTD	Indinavir results in decreased activity of LPL protein	PMID:11786383
increases expression	ISO	RGD:10876	6480464	CTD	Indinavir results in increased expression of LPL mRNA	PMID:11741158
multiple interactions	ISO	RGD:10876	6480464	CTD	[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA	PMID:11741158