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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:49603
Term: lapatinib
Definition: A furan that has formula C29H26ClFN4O4S.
Chemical ID: MESH:C490728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1decreases activityISOMAPK1 (Homo sapiens)6480464CTDlapatinib results in decreased activity of MAPK1 proteinPMID:25221644
Mapk1decreases expressionISOMAPK1 (Homo sapiens)6480464CTDlapatinib results in decreased expression of MAPK1 proteinPMID:16091755
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDlapatinib results in decreased phosphorylation of MAPK1 proteinPMID:20701607 PMID:22233293
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDERBB2 protein affects the reaction [Lapatinib results in decreased activity of MAPK1 protein]; Lapatinib inhibits the reaction [Bortezomib results in increased phosphorylation of MAPK1 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]; Lapatinib inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]PMID:20701607 PMID:25221644 PMID:32890875 PMID:33396024
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