GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk1 | decreases activity | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | lapatinib results in decreased activity of MAPK1 protein | PMID:25221644 | Mapk1 | decreases expression | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | lapatinib results in decreased expression of MAPK1 protein | PMID:16091755 | Mapk1 | decreases phosphorylation | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | lapatinib results in decreased phosphorylation of MAPK1 protein | PMID:20701607 PMID:22233293 | Mapk1 | multiple interactions | ISO | MAPK1 (Homo sapiens) | 6480464 | CTD | ERBB2 protein affects the reaction [Lapatinib results in decreased activity of MAPK1 protein]; Lapatinib inhibits the reaction [Bortezomib results in increased phosphorylation of MAPK1 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]]; Lapatinib inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] | PMID:20701607 PMID:25221644 PMID:32890875 PMID:33396024 | |
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