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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases phosphorylationEXP 6480464CTDAcrolein results in increased phosphorylation of MAPK1 proteinPMID:12487375 PMID:20359552
Mapk1multiple interactionsEXP 6480464CTD[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]PMID:20359552 PMID:24847785
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDAcrolein results in increased phosphorylation of MAPK1 proteinPMID:11329622 PMID:11504702 PMID:15531749 PMID:18951912 PMID:29964147
Mapk1increases phosphorylationISOMapk1 (Mus musculus)6480464CTDAcrolein results in increased phosphorylation of MAPK1 proteinPMID:20153347
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]PMID:11329622 PMID:15531749
Mapk1multiple interactionsISOMapk1 (Mus musculus)6480464CTDRTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of MAPK1 protein]PMID:20153347
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