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GENE - TERM ANNOTATION REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma "DO" "DO", http://en.wikipedia.org/wiki/Hepatocellular_carcinoma "DO" "DO", http://www.omim.org/entry/114550 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tert IEP 11038673RGDprotein:increased expression, increased localization:nucleus 
Tert ISOTERT (Homo sapiens)11530743RGDDNA:hypermethylation:promoter 
Tertdisease_progressionISOTERT (Homo sapiens)11564803RGDDNA:SNP,mutations:promoter:rs2853669 (-245T >C), (-124C > T),(-146C > T)human 
Tertdisease_progressionISOTERT (Homo sapiens)14696767RGDDNA:mutations:promoter: 
Tertdisease_progressionISOTERT (Homo sapiens)152975963RGDassociated with hepatitis B;DNA:SNP: :rs13167280 (human) 
Tertno_associationISOTERT (Homo sapiens)14696769RGD  
TertsusceptibilityISOTERT (Homo sapiens)14696770RGDDNA:mutations, polymorphisms:promoter,intron, exon:rs2736100,rs2736098(human) 
TertsusceptibilityISOTERT (Homo sapiens)150530496RGDDNA:SNPs::rs2736098(human) 
TerttreatmentISOTERT (Homo sapiens)14696768RGD  
Tert ISOTERT (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:16651430 PMID:22634754 PMID:25362482 PMID:25822088
Tert ISOTERT (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hepatocellular carcinomaPMID:23000435 PMID:25741868 PMID:28492532 PMID:28677271
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