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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertincreases activityEXP 6480464CTDTetrachlorodibenzodioxin results in increased activity of TERT proteinPMID:16327978
Tertmultiple interactionsEXP 6480464CTDMYC protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of TERT protein]PMID:16327978
Tertaffects expressionISOTert (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TERT mRNAPMID:21570461 PMID:26377647
Tertincreases activityISOTERT (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased activity of TERT proteinPMID:16327978
Tertincreases expressionISOTERT (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TERT mRNAPMID:16327978 PMID:17141429
Tertincreases expressionISOTert (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TERT mRNAPMID:26290441
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased activity of TERT protein; [Tetrachlorodibenzodioxin co-treated with Estradiol] results in increased expression of TERT mRNA; CYP1A1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TERT mRNA]PMID:16327978 PMID:17141429
Tertmultiple interactionsISOTert (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TERT mRNAPMID:25975270
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