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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCDK2 (Homo sapiens)6480464CTDtroglitazone results in decreased activity of CDK2 proteinPMID:11343236 PMID:12717389
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CDK2 mRNA; troglitazone results in decreased expression of CDK2 proteinPMID:12595159 PMID:15729575 PMID:19140230 PMID:20540935
Cdk2decreases expressionISOCdk2 (Mus musculus)6480464CTDtroglitazone results in decreased expression of CDK2 proteinPMID:15610522
Cdk2increases activityISOCDK2 (Homo sapiens)6480464CTDtroglitazone results in increased activity of CDK2 proteinPMID:11741176
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CDK2 protein]; GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CDK2 protein]; troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein]; troglitazone promotes the reaction [CDKN1A protein binds to CDK2 protein]; troglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein]PMID:12717389 PMID:19908241 PMID:20540935
Cdk2multiple interactionsISOCdk2 (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [troglitazone results in decreased expression of CDK2 protein]; troglitazone results in increased degradation of and results in increased ubiquitination of CDK2 proteinPMID:15610522
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