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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCDK2 (Homo sapiens)6480464CTDIndomethacin results in decreased activity of CDK2 proteinPMID:14566837
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDIndomethacin results in decreased expression of CDK2 protein; Indomethacin results in decreased expression of CDK2 protein modified formPMID:15786552 PMID:19428934
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDIndomethacin promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]PMID:14566837
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