GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdk2 | decreases activity | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in decreased activity of CDK2 protein | PMID:15611077 | Cdk2 | decreases expression | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in decreased expression of CDK2 mRNA | PMID:34821461 | Cdk2 | increases activity | ISO | Cdk2 (Mus musculus) | 6480464 | CTD | Tamoxifen results in increased activity of CDK2 protein | PMID:15642790 | Cdk2 | increases expression | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased expression of CDK2 mRNA; Tamoxifen results in increased expression of CDK2 protein | PMID:20215421 | Cdk2 | multiple interactions | ISO | CDK2 (Homo sapiens) | 6480464 | CTD | [Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1A protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]; [Tamoxifen co-treated with FTI 277] results in decreased activity of [CCNE1 protein binds to CDK2 protein]; Tamoxifen promotes the reaction [CDK2 protein binds to CDKN1A protein] | PMID:12866041 PMID:15611077 | | ||||||||||||||||||||||
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