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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2affects expressionEXP 6480464CTDDiethylnitrosamine affects the expression of CDK2 proteinPMID:26589970
Cdk2increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of CDK2 proteinPMID:11831363 PMID:30779474
Cdk2multiple interactionsEXP 6480464CTDHesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein]PMID:30779474
Cdk2increases expressionISOCdk2 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CDK2 mRNA; Diethylnitrosamine results in increased expression of CDK2 proteinPMID:17854601
Cdk2multiple interactionsISOCdk2 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK2 protein; CDKN1B protein inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK2 protein]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 mRNA]PMID:17620307 PMID:17854601
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