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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2multiple interactionsEXP 6480464CTDAHR affects the reaction [Benzo(a)pyrene results in increased activity of [CCNA2 protein binds to CDK2 protein]]; Benzo(a)pyrene results in increased activity of [CCNA2 protein binds to CDK2 protein]PMID:17141280
Cdk2affects methylationISOCDK2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CDK2 3' UTR; Benzo(a)pyrene affects the methylation of CDK2 promoterPMID:27901495
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CDK2 mRNAPMID:21632981 PMID:21802500
Cdk2decreases expressionISOCdk2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CDK2 mRNA; Benzo(a)pyrene results in decreased expression of CDK2 proteinPMID:35038060
Cdk2increases expressionISOCDK2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CDK2 mRNAPMID:19027820 PMID:32234424 PMID:33411230
Cdk2increases expressionISOCdk2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CDK2 mRNAPMID:22342234
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