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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdk2 Name: cyclin dependent kinase 2

Acc ID: CHEBI:27568 Term: selenium atom Definition: A chalcogen that has formula Se. CasRN: 7782-49-2 Chemical ID: MESH:D012643

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352010	6480464	CTD	[Selenium co-treated with PD 98059] results in decreased expression of CDK2 mRNA [Selenium co-treated with SB 203580] results in increased expression of CDK2 mRNA	PMID:18583539
decreases expression	ISO	RGD:1352010	6480464	CTD	Selenium deficiency results in decreased expression of CDK2 mRNA	PMID:11925459
increases expression	ISO	RGD:1352010	6480464	CTD	Selenium results in increased expression of CDK2 protein	PMID:18583539