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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCDK2 (Homo sapiens)6480464CTDProgesterone results in decreased activity of CDK2 proteinPMID:18850315
Cdk2increases expressionISOCdk2 (Mus musculus)6480464CTDProgesterone results in increased expression of CDK2 mRNAPMID:19847363
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDProgesterone promotes the reaction [CDK2 protein binds to CDKN1A protein]; Progesterone promotes the reaction [CDK2 protein binds to CDKN1B protein]PMID:18850315
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