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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2decreases activityISOCDK2 (Homo sapiens)6480464CTDQuercetin results in decreased activity of CDK2 proteinPMID:11322924
Cdk2decreases expressionISOCDK2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of CDK2 mRNA; Quercetin results in decreased expression of CDK2 proteinPMID:14715546 PMID:20803121 PMID:22431435 PMID:23727915 PMID:25293876
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CDK2 mRNA; Quercetin inhibits the reaction [TNF protein results in increased activity of CDK2 protein]; Quercetin inhibits the reaction [TNF protein results in increased expression of CDK2 protein]; Quercetin promotes the reaction [CDKN1A protein binds to CDK2 protein]; Quercetin promotes the reaction [CDKN1B protein binds to CDK2 protein]PMID:11322924 PMID:12589822 PMID:27514524
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