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GENE - TERM ANNOTATION REPORT

RGD ID: 69368
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn9a
Name: sodium voltage-gated channel alpha subunit 9
Acc ID: DOID:327
Term: syringomyelia
Definition: Longitudinal cavities in the spinal cord, most often in the cervical region, which may extend for multiple spinal levels. The cavities are lined by dense, gliogenous tissue and may be associated with SPINAL CORD NEOPLASMS; spinal cord traumatic injuries; and vascular malformations. Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile sense preserved (sensory dissociation). Lower extremity spasticity and incontinence may also develop. (From Adams et al., Principles of Neurology, 6th ed, p1269)
Definition Source(s): MESH:D013595
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn9a ISOSCN9A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: MORVAN DISEASEPMID:14985375 PMID:15385606 PMID:15955112 PMID:16865694 PMID:17347258 PMID:17470132 PMID:17561957 PMID:18327258 PMID:18347287 PMID:18479393 PMID:18930999 PMID:19304393 PMID:19400878 PMID:19549232 PMID:20301342 PMID:20522430 PMID:21068128 PMID:21258341 PMID:21416599 PMID:21692795 PMID:21719429 PMID:22495306 PMID:23016767 PMID:23020937 PMID:23184456 PMID:23559409 PMID:23662938 PMID:24650168 PMID:24876116 PMID:25253744 PMID:25439579 PMID:25492405 PMID:25524840 PMID:25993546 PMID:25995458 PMID:26068938 PMID:26920677 PMID:27491411 PMID:28202706 PMID:28492532 PMID:29068549 PMID:29911575 PMID:32581362
Scn9a ISOSCN9A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: MORVAN DISEASE | ClinVar Annotator: match by term: Morvan diseasePMID:14985375 PMID:15385606 PMID:15955112 PMID:16865694 PMID:17167479 PMID:17347258 PMID:17470132 PMID:17561957 PMID:18327258 PMID:18347287 PMID:18414213 PMID:18479393 PMID:18518989 PMID:18930999 PMID:19304393 PMID:19369487 PMID:19400878 PMID:19549232 PMID:19763161 PMID:20301342 PMID:20478850 PMID:20522430 PMID:20635406 PMID:21068128 PMID:21094958 PMID:21258341 PMID:21416599 PMID:21692795 PMID:21698661 PMID:21719429 PMID:21939494 PMID:22035805 PMID:22136189 PMID:22495306 PMID:22539570 PMID:22604722 PMID:22826602 PMID:229911575 PMID:22995991 PMID:23016767 PMID:23020937 PMID:23129781 PMID:23184456 PMID:23280954 PMID:23292638 PMID:23450472 PMID:23559409 PMID:23662938 PMID:23874707 PMID:23895530 PMID:24033266 PMID:24088041 PMID:24650168 PMID:24776970 PMID:24817410 PMID:24820863 PMID:24848745 PMID:24876116 PMID:25250524 PMID:25253744 PMID:25309764 PMID:25316021 PMID:25326635 PMID:25333069 PMID:25439579 PMID:25492405 PMID:25524840 PMID:25741868 PMID:25852444 PMID:25993546 PMID:25995458 PMID:26068938 PMID:26264438 PMID:26284228 PMID:26392352 PMID:26467025 PMID:26633545 PMID:26675522 PMID:26920677 PMID:27301361 PMID:27491411 PMID:27504264 PMID:27608006 PMID:27843123 PMID:27884173 PMID:27956748 PMID:28073787 PMID:28202706 PMID:28235406 PMID:28440294 PMID:28492532 PMID:29068549 PMID:29176367 PMID:29264398 PMID:29358611 PMID:29500686 PMID:29911575 PMID:29961513 PMID:29978519 PMID:30316835 PMID:30478917 PMID:30569495 PMID:30642272 PMID:30795902 PMID:30834459 PMID:31193310 PMID:31780880 PMID:32581362 PMID:32613771 PMID:33216760
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