GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slco1b2 | increases expression | ISO | Slco1b2 (Mus musculus) | 6480464 | CTD | fexofenadine results in increased expression of SLCO1B2 mRNA | PMID:24852568 | Slco1b2 | increases uptake | ISO | SLCO1B3 (Homo sapiens) | 6480464 | CTD | SLCO1B3 protein results in increased uptake of fexofenadine | PMID:18245269 | Slco1b2 | multiple interactions | ISO | SLCO1B3 (Homo sapiens) | 6480464 | CTD | [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadine; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine] | PMID:18180276 | |
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