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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69300
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1b2
Name: solute carrier organic anion transporter family member 1B2
Acc ID: CHEBI:28865
Term: taurocholic acid
Definition: A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.
Chemical ID: MESH:D013656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1b2increases uptakeEXP 6480464CTDSLCO1B3 protein results in increased uptake of Taurocholic AcidPMID:19464309
Slco1b2multiple interactionsEXP 6480464CTDBile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of Taurocholic Acid]PMID:19464309
Slco1b2increases expressionISOSlco1b2 (Mus musculus)6480464CTDTaurocholic Acid results in increased expression of SLCO1B2 mRNAPMID:27160211
Slco1b2increases uptakeISOSLCO1B3 (Homo sapiens)6480464CTDSLCO1B3 protein results in increased uptake of Taurocholic AcidPMID:19464309 PMID:30639138
Slco1b2multiple interactionsISOSLCO1B3 (Homo sapiens)6480464CTDTaurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Taurocholic Acid inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]PMID:26134461
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