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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases response to substanceISOAldh2 (Mus musculus)6480464CTDALDH2 protein results in decreased susceptibility to tert-ButylhydroperoxidePMID:15003993
Aldh2increases expressionISOAldh2 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased expression of ALDH2 mRNAPMID:14729362 PMID:15003993 PMID:15336504
Aldh2increases expressionISOALDH2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of ALDH2 mRNAPMID:15336504
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