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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219 Species: Rattus norvegicus RGD Object: Gene Symbol: Aldh2 Name: aldehyde dehydrogenase 2 family (mitochondrial)

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69218	6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA]	PMID:17585979
affects expression	EXP		6480464	CTD	Acetaminophen affects the expression of ALDH2 protein	PMID:16687475 PMID:15800402
affects expression	EXP		6480464	CTD	Acetaminophen affects the expression of ALDH2 mRNA	PMID:15800402
increases expression	ISO	RGD:69218	6480464	CTD	Acetaminophen results in increased expression of ALDH2 protein	PMID:21329376
affects expression	EXP		6480464	CTD	Acetaminophen affects the expression of ALDH2 protein	PMID:15800402 PMID:16687475