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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2increases oxidationISOALDH2 (Homo sapiens)6480464CTDALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenalPMID:22339434
Aldh2multiple interactionsISOAldh2 (Mus musculus)6480464CTD[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenalPMID:21967605
Aldh2multiple interactionsISOALDH2 (Homo sapiens)6480464CTD4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]PMID:22339434 PMID:25263579
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