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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69102
Species: Homo sapiens
RGD Object: Gene
Symbol: JAK1
Name: Janus kinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of JAK1 mRNA; resveratrol results in decreased expression of JAK1 proteinPMID:22254182 PMID:25667456
JAK1decreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of JAK1 proteinPMID:26911335
JAK1multiple interactionsISOJak1 (Mus musculus)6480464CTDIL10 protein affects the reaction [resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]PMID:25576658
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