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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69089 Species: Homo sapiens RGD Object: Gene Symbol: SERPINB5 Name: serpin peptidase inhibitor, clade B (ovalbumin), member 5

Acc ID: CHEBI:4708 Term: doxazosin Definition: A N-acylpiperazine that has formula C23H25N5O5. CasRN: 74191-85-8 Chemical ID: MESH:D017292

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form] SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein] SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein] SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein] SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]	PMID:16007219
increases response to substance	EXP		6480464	CTD	SERPINB5 protein results in increased susceptibility to Doxazosin	PMID:16007219