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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1baffects expressionISOCDKN1B (Homo sapiens)6480464CTDsodium arsenite affects the expression of CDKN1B mRNAPMID:24535192
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of CDKN1B proteinPMID:32890875
Cdkn1bdecreases expressionISOCdkn1b (Mus musculus)6480464CTDsodium arsenite results in decreased expression of CDKN1B proteinPMID:10764629
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDsodium arsenite results in increased expression of CDKN1B proteinPMID:29039521 PMID:30123091
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTD[sodium arsenite co-treated with tetrandrine] results in increased expression of CDKN1B protein; [sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein; Lapatinib inhibits the reaction [sodium arsenite results in decreased expression of CDKN1B protein]; SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein]; sodium arsenite promotes the reaction [CDK4 protein binds to CDKN1B protein]PMID:19082730 PMID:29039521 PMID:30123091 PMID:32890875
Cdkn1bmultiple interactionsISOCdkn1b (Mus musculus)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of CREB1 protein]; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of CREB1 protein; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of MAPK1 protein; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the phosphorylation of MAPK3 protein; [sodium arsenite results in increased abundance of arsenite] affects the reaction [CDKN1B protein affects the expression of PTGS2 mRNA]; CDKN1B protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; CDKN1B protein affects the reaction [sodium arsenite results in increased activity of CASP3 protein]; CDKN1B protein affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; CDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; CDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; CDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of AKT1 protein]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of MAP2K4 protein]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 mRNA]; CDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 protein]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]PMID:20566634 PMID:23639288
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