GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | Mitotane results in increased activity of NR1I2 protein | PMID:31312845 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [Mitotane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Mitotane binds to and results in increased activity of NR1I2 protein; Mitotane promotes the reaction [NCOA1 protein binds to NR1I2 protein]; Mitotane promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Mitotane results in increased expression of CYP3A4 mRNA] | PMID:23179081 PMID:31312845 PMID:33049310 | Nr1i2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | Mitotane binds to and results in increased activity of NR1I2 protein | PMID:33049310 | | ||||||||||||||||||||||
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