GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i2 | decreases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in decreased expression of NR1I2 mRNA | PMID:25868421 PMID:32253466 | Nr1i2 | increases activity | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in increased activity of NR1I2 protein | PMID:28115241 | Nr1i2 | increases expression | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of NR1I2 mRNA | PMID:35337807 | Nr1i2 | increases expression | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | perfluorooctanoic acid results in increased expression of NR1I2 mRNA | PMID:18281256 PMID:30508572 PMID:30685356 PMID:30711707 | Nr1i2 | multiple interactions | ISO | NR1I2 (Homo sapiens) | 6480464 | CTD | [perfluoro-n-nonanoic acid co-treated with perfluorooctanoic acid] results in increased activity of NR1I2 protein; [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid] results in increased activity of NR1I2 protein; perfluorooctanoic acid binds to and results in increased activity of NR1I2 protein | PMID:28115241 PMID:33049310 | Nr1i2 | multiple interactions | ISO | Nr1i2 (Mus musculus) | 6480464 | CTD | Dietary Fats promotes the reaction [perfluorooctanoic acid results in increased expression of NR1I2 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of NR1I2 mRNA] | PMID:18281256 PMID:30711707 | |
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