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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of NR1I2 mRNAPMID:25868421 PMID:32253466
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased activity of NR1I2 proteinPMID:28115241
Nr1i2increases expressionISONR1I2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of NR1I2 mRNAPMID:35337807
Nr1i2increases expressionISONr1i2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of NR1I2 mRNAPMID:18281256 PMID:30508572 PMID:30685356 PMID:30711707
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[perfluoro-n-nonanoic acid co-treated with perfluorooctanoic acid] results in increased activity of NR1I2 protein; [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid] results in increased activity of NR1I2 protein; perfluorooctanoic acid binds to and results in increased activity of NR1I2 proteinPMID:28115241 PMID:33049310
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDDietary Fats promotes the reaction [perfluorooctanoic acid results in increased expression of NR1I2 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of NR1I2 mRNA]PMID:18281256 PMID:30711707
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