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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDDDT results in increased activity of NR1I2 proteinPMID:15548381 PMID:25680588
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[DDT co-treated with Dieldrin] results in increased activity of NR1I2 protein; DDT binds to and results in increased activity of NR1I2 proteinPMID:16054614 PMID:20686338 PMID:25028461 PMID:33049310
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDDDT binds to and results in increased activity of NR1I2 proteinPMID:33049310
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