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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:135338
Term: guggulsterone
Definition: null
Chemical ID: MESH:C023617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2decreases activityISONR1I2 (Homo sapiens)6480464CTDpregna-4,17-diene-3,16-dione results in decreased activity of NR1I2 proteinPMID:12705905
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDpregna-4,17-diene-3,16-dione results in decreased expression of NR1I2 mRNAPMID:29933105
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDpregna-4,17-diene-3,16-dione results in increased activity of NR1I2 proteinPMID:15075359 PMID:29933105
Nr1i2increases activityISONr1i2 (Mus musculus)6480464CTDpregna-4,17-diene-3,16-dione results in increased activity of NR1I2 proteinPMID:15075359
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDpregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [Thapsigargin results in decreased expression of NR1I2 mRNA]PMID:12705905 PMID:25616597
Nr1i2multiple interactionsISONr1i2 (Mus musculus)6480464CTDpregna-4,17-diene-3,16-dione promotes the reaction [NR1I2 protein binds to NCOA1 protein]PMID:15833898
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