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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:75393
Term: Y-27632
Definition: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme.
Chemical ID: MESH:C108830
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDY 27632 inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Y 27632 inhibits the reaction [Glucose results in increased expression of TGFB1 protein]PMID:13678700 PMID:23376009
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDY 27632 inhibits the reaction [ABCB4 gene mutant form results in increased expression of TGFB1 mRNA]PMID:30682444
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDY 27632 inhibits the reaction [Soot results in increased expression of TGFB1 protein]PMID:33792148
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