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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:6541
Term: losartan
Definition: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical ID: MESH:D019808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionEXP 6480464CTDLosartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 proteinPMID:16191423
Tgfb1increases expressionEXP 6480464CTDLosartan results in increased expression of TGFB1 proteinPMID:17784886
Tgfb1multiple interactionsEXP 6480464CTD[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]PMID:12930639 PMID:15331931 PMID:15573910 PMID:17666919 PMID:25233898 PMID:34590760 PMID:38027817
Tgfb1decreases activityISOTgfb1 (Mus musculus)6480464CTD[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 proteinPMID:21152098
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDLosartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein; Losartan results in decreased expression of TGFB1 protein modified formPMID:11369837 PMID:12937228 PMID:32947957
Tgfb1decreases secretionISOTGFB1 (Homo sapiens)6480464CTDLosartan results in decreased secretion of TGFB1 proteinPMID:17330452
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDLosartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]PMID:29859236
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