GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | decreases activity | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Alitretinoin results in decreased activity of TGFB1 protein | PMID:16192631 | Tgfb1 | decreases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Alitretinoin results in decreased expression of TGFB1 mRNA | PMID:16611854 | Tgfb1 | decreases response to substance | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Alitretinoin results in decreased susceptibility to TGFB1 protein | PMID:21152098 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] | PMID:16192631 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [Alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA] | PMID:16611854 | | ||||||||||||||||||||||
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