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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDdimethyl mercaptosuccinate inhibits the reaction [Sodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Sodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Sodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]; Sodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of IL6 protein]; Sodium Selenite inhibits the reaction [TGFB1 protein results in increased expression of VEGFA protein]PMID:16757516
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDTGFB1 protein affects the reaction [[Dexamethasone co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in decreased expression of SP7 protein]; TGFB1 protein inhibits the reaction [[Dexamethasone co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in decreased expression of RUNX2 protein]PMID:32324263
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