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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:46661
Term: asbestos
Definition: Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements.
Chemical ID: MESH:D001194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDAsbestos results in increased expression of TGFB1 mRNAPMID:11394717
Tgfb1affects response to substanceISOTGFB1 (Homo sapiens)6480464CTDTGFB1 gene SNP affects the susceptibility to Asbestos; TGFB1 protein polymorphism affects the susceptibility to AsbestosPMID:19349911 PMID:24142982
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDAsbestos results in decreased expression of TGFB1 mRNAPMID:22076105
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDAsbestos results in increased expression of TGFB1 mRNAPMID:22076105 PMID:22398240
Tgfb1increases expressionISOTgfb1 (Mus musculus)6480464CTDAsbestos results in increased expression of TGFB1 mRNAPMID:11394717
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDTNF protein promotes the reaction [Asbestos results in increased expression of TGFB1]PMID:11394717
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