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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of TGFB1 proteinPMID:12960047 PMID:15677882
Tgfb1increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of TGFB1 mRNAPMID:17005392
Tgfb1multiple interactionsEXP 6480464CTD[Bromocriptine co-treated with vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-] inhibits the reaction [Diethylstilbestrol results in increased expression of TGFB1 protein]; Bromocriptine inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein]; vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- inhibits the reaction [Diethylstilbestrol results in decreased expression of TGFB1 protein]PMID:15677882
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDDiethylstilbestrol results in decreased expression of TGFB1 mRNAPMID:17394237
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